UK Drug Safety Update · May 15, 2025

Thiopurines and intrahepatic cholestasis of pregnancy

Intrahepatic cholestasis of pregnancy rarely reported with thiopurine class drugs; new safety restriction advised for pregnant patients.

Low obligation Product class Pharmaceuticals UK Pharmacovigilance

Intrahepatic cholestasis of pregnancy (ICP) has been rarely reported in patients treated with azathioprine products and is believed to be a risk applicable to all drugs in the thiopurine class (azathioprine, mercaptopurine a…

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