There have been reports of worsening nasal congestion (rebound congestion) when the effects of nasal decongestant sprays or drops containing xylometazoline hydrochloride and oxymetazoline hydrochloride, wear off.
UK Drug Safety Update · April 30, 2026
Nasal decongestant sprays and drops containing xylometazoline hydrochloride / oxymetazoline hydrochloride: increased risk of rebound congestion, rhinitis medicamentosa, and tachyphylaxis with overuse
Safety alert on rebound congestion and rhinitis medicamentosa risk with overuse of nasal decongestant sprays and drops containing xylometazoline or oxymetazoline.
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