Warfarin: be alert to the risk of drug interactions with tramadol

- warfarin is a coumarin-derived vitamin K antagonist which has a low therapeutic index, so continue to exercise caution when co-prescribing warfarin with other drugs, to minimise the risk of drug interactions

- ask patients about all the medicines that they are currently taking

- be aware of the risk of increased INR when warfarin and tramadol are used together, with a risk of major bruising and bleeding which could be life-threatening

- consult the product information of any new concomitant therapy for specific guidance on use with warfarin and consider whether warfarin dose adjustment is required

- consider whether additional monitoring of INR is required when starting tramadol or another concomitant medicine

- ensure patients are aware of the need to seek medical treatment should they notice the signs of a major bleeding event

- caution should also be taken if tramadol is co-prescribed with other coumarin-derived anticoagulants such as acenocoumarol

- warfarin can interact with some medicines, such as tramadol, leading to an increased risk of bleeding

- you should seek medical treatment and have an urgent International Normalised Ratio test should you experience any of the following symptoms:

- prolonged nose bleeds (more than 10 minutes)

- blood in vomit, sputum (phlegm), stool (poo) or urine (pee)

- severe or unexplained bruising

- severe bleeding gums

- unusual headaches (headaches with blurred vision, slurred speech, loss of movement, feeling or being sick, fits, loss of consciousness, dizziness)

- women who experience heavy or increased bleeding during their menstrual period or any other heavy vaginal bleeding

- inform your healthcare professional that you are taking warfarin and carry your anticoagulant alert card with you at all times

- inform your healthcare professional of all the medicines you are currently taking

- do not take any new medicines without first discussing this with your healthcare professional

- do not stop taking warfarin without first discussing this with your healthcare professional

Risk of adverse drug interaction with tramadol

The MHRA has received a Coroner’s report following the death of a patient who died from a bleed on the brain, following concurrent treatment with warfarin and tramadol. Taking warfarin and tramadol together may increase a patient’s INR and increase the risk of bleeding. The Coroner raised concerns that the interaction between warfarin and tramadol was not well known and emphasised the need to highlight this interaction to healthcare professionals.

Warfarin is a coumarin-derived vitamin K antagonist used for prevention and treatment of blood clots. It is used to prevent embolisation in rheumatic heart disease and, atrial fibrillation and after insertion of prosthetic heart valves. Warfarin is also used in the prevention and treatment of venous thrombosis and pulmonary embolism and treatment of transient ischaemic attacks.